My entire adult life was destroyed by this. I have always wondered why I couldn't keep a job for more than 3 days before I couldn't get out of bed to go to work. I would present myself to doctors in an ER and tell them that I had to take 1,600mgs of caffeine just to get out of bed and for over 25 years I've been asking them "why am I so tired all the time"? All I got was chronic fatigue syndrome. Now I know that my hypocretin/orexin-1 level is 30.1% , typically it should be between 40-60% and at 40% that's determined to be undetectable. I've learned to be able to describe my symptoms in detail to doctors that better helps them understand what's wrong with me.